Hydrochloric Acid → HCID 58012040, compound

Participants

Reaction Conditions

Reaction Steps

180 mg (0.31 mmol) of methyl 3-(3-(4-chlorophenyl)-1-[2-(1-methyl-1-[3-(trifluoromethyl)phenyl]-ethylamino)-2-oxoethyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-ylmethyl)-benzoate (Example 411) are dissolved in 3 ml of methanol and 3 ml of THF, treated with 0.3 ml of 2 N aqueous sodium hydroxide and stirred for 1 hr at 70° C. The reaction mixture is then introduced into ca. of 10 ml water, brought to pH 4 with 1 N hydrochloric acid, and stirred for 2 hrs at RT. The resulting precipitate is filtered off at the pump, washed with water and freed of solvent residues under high vacuum. 154 mg (88% of theory) of the target compound are obtained.

Provenance & Evidence