Ammonium Chloride → HCID 58012041, compound

Participants

Reaction Steps

62 mg (0.12 mmol) of 2-[3-(4-chlorophenyl)-5-oxo-4-(2-oxobutyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-acetamide from Example 443 are dissolved in 2 ml of methanol and treated at RT with 4.7 mg (0.12 mmol) of sodium borohydride. This is stirred for 1 hr at RT. It is then treated with saturated ammonium chloride solution and extracted with 10 ml of ethyl acetate. The organic phase is dried over sodium sulphate, filtered and concentrated. 57 mg (92% of theory) of the target compound are thus obtained.

Provenance & Evidence