Ammonium Chloride → HCID 58011783, compound

Participants

Reaction Steps

103 mg (0.21 mmol) of 2-[3-(4-chlorophenyl)-4-(2-oxoethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-acetamide from Example 401 are dissolved in 1 ml of THF and treated at −78° C. with 1.1 ml (0.54 mmol) of cyclopropylmagnesium bromide (0.5 M solution in THF). This is stirred for 3 hrs at RT and then for a further 2 hrs at 50° C. For the workup, it is treated with saturated ammonium chloride solution and extracted twice with 10 ml of ethyl acetate each time. The combined organic phases are dried over sodium sulphate, filtered and concentrated in vacuo. The crude product is purified by preparative HPLC [Method 10]. 12 mg (11% of theory) of the target compound are thus obtained.

Provenance & Evidence