Cesium carbonate → HCID 58011780, compound

Participants

Reaction Steps

92.6 mg (0.475 mmol) of tert.-butyl bromoacetate are added to 150.0 mg of (0.365 mmol) 2-[3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[3-(trifluoromethyl)phenylmethyl]-acetamide from Example 242A and 178.5 mg (0.548 mmol) of caesium carbonate in 5.0 ml of acetone and heated for 5 hrs under reflux. For the workup, the reaction mixture is concentrated after cooling, the residue is partitioned between water and ethyl acetate, the organic phase separated and the aqueous phase extracted several times more with ethyl acetate. The combined organic phases are concentrated and the residue purified by preparative HPLC [Method 12]. 139 mg (73% of theory) of the target compound are thus obtained.

Provenance & Evidence