Hydrochloric Acid → HCID 67485090, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-[1-allyl-1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxymethyl)-but-3-enyl]-thiophene-2-carboxylic acid methyl ester (0.186 g, 0.361 mmol) in THF (4.0 mL) is treated with LiOH (1N aqueous, 4.0 mL, 4.0 mmol), warmed to 70° C., and stirred overnight. The reaction mixture is cooled to rt., acidified with HCl (1N aqueous, 4.2 mL), and extracted with EtOAc (3×10 mL). The combined extracts are dried over MgSO4, filtered, and conc. to provide 5-[1-allyl-1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxymethyl)-but-3-enyl]-thiophene-2-carboxylic acid (0.171 g, 94%) as a white foam. MS (ES): 501.4 [M+H]+.

Provenance & Evidence