Hydrochloric Acid → HCID 67484499, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-[1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxymethyl)-cyclopent-3-enyl]-thiophene-2-carboxylic acid methyl ester (0.239 g, 0.492 mmol) in THF (5.0 mL) is treated with LiOH (1N aqueous, 5.0 mL, 5.0 mmol), warmed to 70° C., and stirred overnight. The reaction mixture is cooled to rt, acidified with HCl (1N aqueous, 5.2 mL), and extracted with EtOAc (3×10 mL). The combined extracts are dried over MgSO4, filtered, and concentrated to provide 5-[1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxymethyl)-cyclopent-3-enyl]-thiophene-2-carboxylic acid (0.210 g, 90%) as a yellow foam. MS (ES): 471.2 [M−H]−.

Provenance & Evidence