Boronic acid, (4-ethylphenyl)- → HCID 59355997, compound

HRID 660997Notes

Reaction equation

HRID 660997 reaction equation
[CH3:1][O:2][C:3](=[O:31])[CH2:4][CH2:5][NH:6][C:7]([C:9]1[S:10][C:11]([CH:14]([O:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25](I)=[C:24]([CH3:30])[CH:23]=2)[CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:13]=1)=[O:8].[CH2:32]([C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1)[CH3:33]>>[CH3:1][O:2][C:3](=[O:31])[CH2:4][CH2:5][NH:6][C:7]([C:9]1[S:10][C:11]([CH:14]([O:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25]([C:37]3[CH:38]=[CH:39][C:34]([CH2:32][CH3:33])=[CH:35][CH:36]=3)=[C:24]([CH3:30])[CH:23]=2)[CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:13]=1)=[O:8]

Participants

3

Reactant 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 59355941HCID 59355941, compound

Product 1

HCID 59355997HCID 59355997, compound

Procedure

This compound is made by the general method as exemplified in Preparation 77 using 3-({5-[4,4,4-trifluoro-1-(4-iodo-3,5-dimethyl-phenoxy)-butyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester - chiral Isomer 1 and 4-ethyl-phenyl boronic acid as the starting materials. MS(ES): 548.3 [M+H]+.

Sources & evidence

ORD record
ord-fc0a259a2bfe46f09c9a1739103cf1e1
Source dataset
uspto-grants-2011_12
Patent number
US08084489B2

Reaction notes

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