Methyl 3-aminopropanoate hydrochloride → (+/-)-3-({4-Chloro-5-[1-(2,6-dimethyl-4'-trifluoromethyl-biphenyl-4-yloxy)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester

Participants

Reaction Steps

This compound is made by the general method as exemplified in Preparation 94 using 2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-ol and 4-chloro-5-(1-hydroxy-propyl)-thiophene-2-carboxylic acid methyl ester in Step A and 3-amino-propionic acid methyl ester hydrochloride salt in Step C as the starting materials to provide (±)-3-({4-chloro-5-[1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxy)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.094 g) as a white foam. MS (ES): 552.2 [M−H]−.

Provenance & Evidence