Methyl 3-aminopropanoate hydrochloride → (+/-)-3-({5-[1-(4'-Tert-butyl-2,6-dimethyl-biphenyl-4-ylsulfanyl)-ethyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester

Participants

Reaction Steps

This compound is made by the general method as exemplified in Preparation 107 using 4′-tert-butyl-2,6-dimethyl-biphenyl-4-thiol and (±)-5-(1-hydroxy-ethyl)-thiophene-2-carboxylic acid ethyl ester in Step A and 3-amino-propionic acid methyl ester hydrochloride salt in Step C as the starting materials to provide (±)-3-({5-[1-(4′-tert-butyl-2,6-dimethyl-biphenyl-4-ylsulfanyl)-ethyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.279 g) as a white foam. MS (ES): 508.3 [M−H]−.

Provenance & Evidence