Hydrochloric Acid → HCID 11951430, compound

Participants

Reaction Steps

A solution of 3-({5-[1-(4′-trifluoromethyl-biphenyl-4-yloxy)-ethyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (chiral Isomer 1) (170 mg, 0.356 mmol) in methanol (7.1 mL) is treated with 5N NaOH (0.712 mL) and shaken at rt for 2 h. The reaction is neutralized with 1N HCl (0.748 mL), and extracted into ethyl acetate (2×). The combined organic layers are dried and concentrated, giving the title compound (142 mg). MS (ES): 464.2 [M+H]+.

Provenance & Evidence