Hydrochloric Acid → HCID 11951964, compound

Participants

Reaction Steps

A solution of 3-({5-[2,2-dimethyl-1-(2-methyl-4′-trifluoromethyl-biphenyl-4-yloxy)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (chiral Isomer 1) (36 mg, 0.067 mmol) in methanol (1.0 mL) is treated with 5N NaOH (0.067 mL) and shaken at rt overnight. The reaction is neutralized with 1N HCl (0.068 mL), and extracted into ethyl acetate (2×). The combined organic layers are dried and concentrated, giving the title compound (21.6 mg). MS (ES): 520.3 [M+H]+.

Provenance & Evidence