Hydrochloric Acid → HCID 11951967, compound

Participants

Reaction Steps

A solution of 3-({5-[1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxy)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (chiral Isomer 1) (79.6 mg, 0.153 mmol) in methanol (1.54 mL) is treated with 5N NaOH (0.154 mL) and shaken at rt overnight. The reaction is neutralized with 1N HCl (0.158 mL), and extracted into ethyl acetate (2×). The combined organic layers are dried and concentrated, giving the title compound (76 mg). MS (ES): 506.4 [M+H]+.

Provenance & Evidence