4-tert-Butylphenylboronic acid → HCID 11951968, compound

HRID 661012Notes

Reaction equation

HRID 661012 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][CH2:5][NH:6][C:7]([C:9]1[S:10][C:11]([CH:14]([O:17][C:18]2[CH:23]=[C:22]([CH3:24])[C:21](I)=[C:20]([CH3:26])[CH:19]=2)[CH2:15][CH3:16])=[CH:12][CH:13]=1)=[O:8].[C:28]([C:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([C:32]1[CH:37]=[CH:36][C:35]([C:21]2[C:22]([CH3:24])=[CH:23][C:18]([O:17][CH:14]([C:11]3[S:10][C:9]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:27])=[O:8])=[CH:13][CH:12]=3)[CH2:15][CH3:16])=[CH:19][C:20]=2[CH3:26])=[CH:34][CH:33]=1)([CH3:31])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 59355939HCID 59355939, compound

Product 1

HCID 11951968HCID 11951968, compound

Procedure

This compound is made by the general method as exemplified in Example 44 using 3-({5-[1-(4-iodo-3,5-dimethyl-phenoxy)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (isomer 1) and (4-tert-butyl)phenylboronic acid as the starting materials. MS (ES): 494.4 [M+H]+.

Sources & evidence

ORD record
ord-a539a1cdff6f4ca5bca7eaffe642a0e3
Source dataset
uspto-grants-2011_12
Patent number
US08084489B2

Reaction notes

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