Hydrochloric Acid → HCID 11951967, compound

Participants

Reaction Steps

To a solution of 3-({5-[1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxy)-2-methyl-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.0390 mg, 0.0731 mmol) in THF (2.0 mL) is added lithium hydroxide (1N aqueous, 2.0 mL) at rt and stirred overnight. The reaction mixture is acidified with 1 N HCl (2.4 mL), extracted with EtOAc (3×10 mL), dried over MgSO4, filtered, and conc. to provide the title compound (0.0356 g, 94%). MS (ES): 520.0 [M+H]+.

Provenance & Evidence