Hydrochloric Acid → HCID 11951969, compound

Participants

Reaction Steps

A solution of 3-({5-[1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-yloxy)-3-methyl-butyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (Isomer 1) (91 mg, 0.166 mmol) in methanol (1.66 mL) is treated with 5N NaOH (0.166 mL) and shaken at rt for 2 h. The reaction is neutralized with 1N HCl (0.170 mL), and extracted into ethyl acetate (2×). The combined organic layers are dried and concentrated, giving the title compound (142 mg). MS (ES): 534.4 [M+H]+.

Provenance & Evidence