Hydrochloric Acid → HCID 11951968, compound

Participants

Reaction Steps

A solution of 3-({5-[1-(4′-tert-butyl-2,6-dimethyl-biphenyl-4-yloxy)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (Isomer 2) (90.2 mg, 0.178 mmol) in methanol (1.8 mL) is treated with 5N NaOH (0.178 mL) and shaken at rt overnight. The reaction is neutralized with 1N HCl (0.182 mL), and extracted into ethyl acetate (2×). The combined organic layers are dried and concentrated, giving the title compound (70.5 mg). MS (ES): 494.3 [M+H]+.

Provenance & Evidence