反应详情

1.58 g of the above 5-(5-trifluoromethyl-2-furylmethylene)rhodanine, 23 ml of 1 N sodium hydroxide solution and 25 ml of water are stirred under nitrogen at room temperature for 10 hours. After cooling with an ice bath and acidification with concentrated hydrochloric acid to pH 1.5, the resulting slurry is filtered to yield a slightly brown precipitate which is washed with 50 ml of water by stirring at room temperature under nitrogen and filtered to yield 0.8 g of slightly brown crystals (yield 60%) of α-mercapto-β-(5-trifluoromethyl-2-furyl)acrylic acid. M.P. 158° C.

1. temperatureAfter cooling with an ice bath
2. filtrationacidification with concentrated hydrochloric acid to pH 1.5, the resulting slurry is filtered
3. customto yield a slightly brown precipitate which
4. washis washed with 50 ml of water
5. filtrationfiltered