HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate | HCID 58002139 | — |
| Product | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 58002447 | — |
Reaction Steps
According to General Method 4A, 22.19 g (39.90 mmol) of the compound from Example 3A and 44.78 g (399.0 mmol) of potassium tert-butoxide were reacted. The reaction led selectively to the cis isomer. Yield: 18.29 g (100% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-044de0459b564393abedadd92dd60c91 |
| Source note | uspto-grants-2011_12 |