HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromopyridine-3-carboxylate → 5-(4-Trifluoromethoxy-phenyl)-nicotinic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Reactant | 4-(Trifluoromethoxy)phenylboronic acid | HCID 2734386 | — |
| Product | 5-(4-Trifluoromethoxy-phenyl)-nicotinic acid methyl ester | HCID 58002591 | — |
Reaction Steps
According to General Method 1A, 23 g (105 mmol) of methyl 5-bromonicotinate and 26 g (126 mmol, 1.2 eq.) of 4-trifluoromethoxyphenylboronic acid were reacted. Yield: 14 g (41% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-d094d44dc14f47b89f50330c4566a8de |
| Source note | uspto-grants-2011_12 |