Morpholine → 2-[o-(beta-Morpholino-ethoxy)-styryl]-pyridine

HRID 66121Notes

Reaction equation

HRID 66121 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[O:22]1[CH2:23][CH2:24][N:19]([CH2:2][CH2:3][O:4][C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:20][CH2:21]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 53663043HCID 53663043, compound

Product 1

HCID 537829732-[o-(beta-Morpholino-ethoxy)-styryl]-pyridine

Procedure

2-[o-(β-Morpholino-ethoxy)-styryl]-pyridine was prepared from 2-[o-(β-chloro-ethoxy)-styryl]-pyridine (m.p. 57°-58° C.) and morpholine, and the free base was converted into its dihydrochloride, yielding 53% of theory of the compound of the formula ##STR10## which had a melting point of 248° C.

Workup

  1. customyielding 53% of theory of the compound of the formula ##STR10## which

Sources & evidence

ORD record
ord-8b213ea6f9284364a81a42d869b0dec2
Source dataset
uspto-grants-1978_12
Patent number
US04130650

Reaction notes

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