HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 5-(3-fluoro-4-vinylphenyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-1-ethenyl-2-fluorobenzene | HCID 16660774 | — |
| Reactant | [5-(Methoxycarbonyl)pyridin-3-yl]boronic acid hydrochloride | HCID 66890177 | — |
| Product | Methyl 5-(3-fluoro-4-vinylphenyl)nicotinate | HCID 58116499 | — |
Reaction Steps
2.5 g (11.2 mmol) of 4-bromo-2-fluoro-1-vinylbenzene were reacted according to General Method 1A with 3.2 g (14.5 mmol) of [5-(methoxycarbonyl)pyridin-3-yl]boronic acid hydrochloride. The release of the hydrochloride was achieved by additional addition of 1.70 g (12.3 mmol) of potassium carbonate. Yield: 1.9 g (61% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-05d80582f03b4f8facb1c032ebfd67a1 |
| Source note | uspto-grants-2011_12 |