HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 5-(4-Ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 5-(4-ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate | HCID 58116462 | — |
| Product | 5-(4-Ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58116523 | — |
Reaction Steps
According to General Method 4A, 1.2 g (3.0 mmol) of methyl 5-(4-ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate were reacted with 3.4 g (30.4 mmol) of potassium tert-butoxide. Yield: 599 mg (50% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-95d825d4ff294e6d808f2696942bc998 |
| Source note | uspto-grants-2011_12 |