HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 5-[4-(difluoromethoxy)phenyl]nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Bromo-4-(difluoromethoxy)benzene | HCID 2737007 | — |
| Reactant | [5-(Methoxycarbonyl)pyridin-3-yl]boronic acid hydrochloride | HCID 66890177 | — |
| Product | Methyl 5-[4-(difluoromethoxy)phenyl]nicotinate | HCID 58116524 | — |
Reaction Steps
10.0 g (44.8 mmol) of 4-(difluoromethoxy)bromobenzene were reacted according to General Method 1A with 14.6 g (67.3 mmol) of [5-(methoxycarbonyl)pyridin-3-yl]boronic acid hydrochloride. The release of the hydrochloride was achieved by additional addition of 6.80 g (49.3 mmol) of potassium carbonate. Yield: 8.6 g (67% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-b142ee1a5644421d8e0650c1e412fa15 |
| Source note | uspto-grants-2011_12 |