HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661227Generated: November 3, 2026
Potassium Carbonate → Methyl 5-(4-ethylphenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate
https://huagongshe.com/reaction/661227
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 3-Methyl 1-(4-nitrophenyl) 5-(4-ethylphenyl)piperidine-1,3-dicarboxylate | HCID 58002382 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 5-(4-ethylphenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate | HCID 58116530 | — |
Reaction Steps
5.00 g (12.1 mmol) of the compound from Example 45A, 3.57 g (36.4 mmol) of thiomorpholine and 5.03 g (36.4 mmol) of potassium carbonate were added to 76 ml of DMF and heated in 5 portions in a single-mode microwave (Emrys Optimizer) at 150° C. for 1.5 h. For workup, the reaction solutions were combined and filtered, and the residue was purified by means of preparative HPLC. Yield: 3.07 g (67% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084469B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-e1e745e76bcf4f54811ca5e5b4640a84 |
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| Source note | uspto-grants-2011_12 |
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