反应详情

温度

60 °C

To a solution of 733 mg (1.71 mmol) of the compound from Example 57A in methanol (32 ml) were added, at RT, 1.92 g (17.1 mmol) of potassium tert-butoxide. The mixture was stirred at 60° C. for 5 h. For workup, the methanol was removed under reduced pressure, and the residue was admixed with water and acidified (pH=1) with aqueous 1 N hydrochloric acid solution. The mixture was extracted with ethyl acetate, and the organic phase was dried with magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 735 mg (99% of theory)

1. customFor workup, the methanol was removed under reduced pressure
2. extractionThe mixture was extracted with ethyl acetate
3. dry with materialthe organic phase was dried with magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure