Trifluoroacetic acid → 3-(3-Ethoxy-1,2,4-oxadiazol-5-yl)-5-[3-fluoro-4-(trifluoromethoxy)phenyl]piperidine

Participants

Reaction Steps

387 mg (0.50 mmol) of tert-butyl 3-(3-ethoxy-1,2,4-oxadiazol-5-yl)-5-[3-fluoro-4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate were initially charged in 30 ml of dichloromethane and admixed with 0.38 ml (567 mg, 4.97 mmol) of trifluoroacetic acid. The reaction mixture was stirred at RT for 16 hours, admixed with the same amount of trifluoroacetic acid and stirred at RT for a further 3.5 hours. The reaction mixture was concentrated under reduced pressure, taken up in ethyl acetate and washed twice with saturated aqueous sodium hydrogencarbonate solution. The organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 195 mg (96% of theory)

Provenance & Evidence