Triethylamine → HCID 58116569, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 32 mg (0.08 mmol) of the compound from Example 66A in dichloromethane (1.0 ml) was admixed with 0.04 ml (29 mg, 0.29 mmol) of triethylamine and then, at 0° C., 17 mg (0.08 mmol) of 4-nitrophenyl chloroformate were added. The mixture was stirred at 0° C. for 2 h, then warmed to RT and stirred for 1 h. The reaction solution was washed with saturated aqueous sodium hydrogencarbonate solution and water, and the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 50.5 mg (79% of theory, purity 70%)

Provenance & Evidence