反应详情

温度

60 °C

To a solution of 4.29 g (9.57 mmol) of the compound from Example 78A in methanol (190 ml) were added, at RT, 10.7 g (112 mmol) of potassium tert-butoxide. The mixture was stirred at 60° C. overnight. For workup, the methanol was removed under reduced pressure, and the residue was admixed with water and acidified (pH=1) with aqueous 1 N hydrochloric acid solution. The mixture was extracted with ethyl acetate, and the organic phase was dried with magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 3.94 g (76% of theory, purity 80%).

1. customFor workup, the methanol was removed under reduced pressure
2. extractionThe mixture was extracted with ethyl acetate
3. dry with materialthe organic phase was dried with magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure