HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromopyridine-3-carboxylate → Methyl 5-[3-fluoro-4-(trifluoromethyl)phenyl]nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Reactant | 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester | HCID 46739054 | — |
| Product | Methyl 5-[3-fluoro-4-(trifluoromethyl)phenyl]nicotinate | HCID 58116580 | — |
Reaction Steps
According to General Method 1A, 18.2 g (approx. 62.81 mmol) of the compound from Example 80A and 5.4 g (25.1 mmol) of methyl 5-bromonicotinate were reacted. Yield: 7.0 g (36% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-76e317b86a9a4f4a9ab7d6286d065bd3 |
| Source note | uspto-grants-2011_12 |