HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-fluorobenzotrifluoride → Methyl 5-[2-fluoro-4-(trifluoromethyl)phenyl]nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-fluorobenzotrifluoride | HCID 142414 | — |
| Reactant | 3-(Methoxycarbonyl)pyridine-5-boronic acid, pinacol ester | HCID 17750257 | — |
| Product | Methyl 5-[2-fluoro-4-(trifluoromethyl)phenyl]nicotinate | HCID 58116584 | — |
Reaction Steps
According to General Method 1A, 5.0 g (20.6 mmol) of 1-bromo-2-fluoro-4-(trifluoromethyl)benzene and 13.53 g (51.44 mmol) of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate were reacted. Yield: 3.6 g (58% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-8c411bc313fa43e3b081232f6542d02e |
| Source note | uspto-grants-2011_12 |