Potassium Carbonate → HCID 58116474, compound

Participants

Reaction Conditions

Reaction Steps

1.28 g (2.73 mmol) of the compound from Example 88A, 1.41 g (13.6 mmol) of thiomorpholine and 1.13 g (8.18 mmol) of potassium carbonate were added to 18 ml of DMF, and the mixture was heated in a single-mode microwave (Emrys Optimizer) at 150° C. for 40 minutes. For workup, the reaction solution was concentrated by rotary evaporation, and the residue was admixed with water. After addition of ethyl acetate and phase separation, the organic phase was washed with aqueous 1 N hydrochloric acid solution, dried (magnesium sulphate), filtered and concentrated under reduced pressure. This gave 946 mg of crude product in 72% purity (LC-MS), which was reacted without any further purification steps.

Provenance & Evidence