Potassium tert-butoxide → HCID 58116564, compound

HRID 661258Notes

Reaction equation

HRID 661258 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][N:16]([C:18]([N:20]2[CH2:25][CH2:24][S:23][CH2:22][CH2:21]2)=[O:19])[CH2:15][CH:14]([C:26]([O:28]C)=[O:27])[CH2:13]1.CC(C)([O-])C.[K+]>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][N:16]([C:18]([N:20]2[CH2:25][CH2:24][S:23][CH2:22][CH2:21]2)=[O:19])[CH2:15][CH:14]([C:26]([OH:28])=[O:27])[CH2:13]1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 58116474HCID 58116474, compound

Product 1

HCID 58116564HCID 58116564, compound

Procedure

According to General Method 4A, 945 mg (1.56 mmol) of the compound from Example 89A were reacted with 1.74 g (15.5 mmol) of potassium tert-butoxide. This gave 762 mg of crude product in 69% purity (LC-MS), which was reacted without any further purification steps.

Sources & evidence

ORD record
ord-edca7183492a45e99b8c15e3229e74e3
Source dataset
uspto-grants-2011_12
Patent number
US08084469B2

Reaction notes

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