HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene → Methyl 5-[3-fluoro-4-(trifluoromethoxy)phenyl]nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene | HCID 2782217 | — |
| Reactant | 3-(Methoxycarbonyl)pyridine-5-boronic acid, pinacol ester | HCID 17750257 | — |
| Product | Methyl 5-[3-fluoro-4-(trifluoromethoxy)phenyl]nicotinate | HCID 58116516 | — |
Reaction Steps
According to General Method 1A, 8.0 g (30.9 mmol) of 4-bromo-2-fluoro-1-(trifluoromethoxy)benzene and 20.13 g (77.22 mmol) of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate were reacted. Yield: 8.02 g (69% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-635e5e43acb7453d8990aae2780ddf59 |
| Source note | uspto-grants-2011_12 |