Ethanol → (3-{3-[Cyclopropyl(methyl)amino]-1,2,4-oxadiazol-5-yl}-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl)(morpholin-4-yl)methanone

Participants

Reaction Conditions

Reaction Steps

To a solution of 109 mg (0.245 mmol) of the oxadiazole from Example 23A in 2.0 ml of ethanol were added 523 mg (7.35 mmol) of cyclopropylmethylamine, and then the reaction mixture was stirred in the microwave at 90° C. for 12 h. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 42.0 mg (36% of theory)

Provenance & Evidence