Isopropylamine → {3-[3-(Isopropylamino)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

Participants

Reaction Steps

To a solution of 100 mg (0.225 mmol) of the oxadiazole from Example 23A in 1.5 ml of ethanol were added 266 mg (4.50 mmol) of isopropylamine, and then the reaction mixture was stirred in the microwave at 80 for 2 h. Another 266 mg (4.50 mmol) of isopropylamine were added and the mixture was stirred in the microwave at 80° C. for a further 2 h. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 69.0 mg (66% of theory)

Provenance & Evidence