2-Methoxyethylamine → HCID 49819420, compound

Participants

Reaction Steps

To a solution of 100 mg (0.225 mmol) of the oxadiazole from Example 23A in 3.0 ml of ethanol were added 25.6 mg (0.337 mmol) of 2-methoxyethylamine, and then the reaction mixture was stirred at 60 for 3 h. Another 51.2 mg (0.674 mmol) of 2-methoxyethylamine were added, and the mixture was stirred at 60° C. for a further 12 h. This was followed by stirring in the microwave at 80° C. for a further 24 h and then at 120° C. for 45 min. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 15.3 mg (12% of theory)

Provenance & Evidence