HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Ethylamino)ethanol → HCID 49819423, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Ethylamino)ethanol | HCID 8072 | — |
| Reactant | {3-(3-Chloro-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone | HCID 58116540 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 49819423 | HCID 49819423 | — |
Reaction Steps
To a solution of 150 mg (0.337 mmol) of the oxadiazole from Example 23A in 2.25 ml of ethanol were added 601 mg (6.74 mmol) of 2-(ethylamino)ethanol, and then the reaction mixture was stirred in the microwave at 80 for 2 h. Another 601 mg (6.74 mmol) of 2-(ethylamino)ethanol were added and the mixture was stirred in the microwave at 100 for a further 7 h. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 28.3 mg (17% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-d98a66707e0742c1af2d99eff3ee3435 |
| Source note | uspto-grants-2011_12 |