2-(Methylamino)ethanol → HCID 49819424, compound

Participants

Reaction Steps

To a solution of 150 mg (0.337 mmol) of the oxadiazole from Example 23A in 2.25 ml of ethanol were added 507 mg (6.74 mmol) of 2-(methylamino)ethanol, and then the reaction mixture was stirred in the microwave at 80 for 2 h. Another 507 mg (6.74 mmol) of 2-(methylamino)ethanol were added and the mixture was stirred in the microwave at 80 for a further 2 h and then at 100° C. for 30 min. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 53.7 mg (33% of theory)

Provenance & Evidence