HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661283Generated: November 1, 2026
Sodium ethoxide → HCID 49819700, compound
https://huagongshe.com/reaction/661283
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | {3-(3-Chloro-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone | HCID 58116540 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 49819700 | HCID 49819700 | — |
Reaction Steps
To a solution of 150 mg (0.337 mmol) of the oxadiazole from Example 23A in 6.25 ml of ethanol were added 229 mg (3.37 mmol) of sodium ethoxide, and then the reaction mixture was stirred at RT for 3 days and at 40° C. for 2 days. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 16.8 mg (11% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08084469B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-c9ee3fd7afa04ec2b2121e9ad52f8c2e |
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| Source note | uspto-grants-2011_12 |
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