反应详情

To a solution of 100 mg (0.225 mmol) of the oxadiazole from Example 23A in 8.0 ml of methanol were added 60.79 mg (1.124 mmol) of sodium methoxide, and then the reaction mixture was stirred under reflux for 18 h. The reaction mixture was admixed with water and extracted with dichloromethane. The organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by means of preparative HPLC. Yield: 32.0 mg (31% of theory)

1. temperatureunder reflux for 18 h
2. extractionextracted with dichloromethane
3. dry with materialThe organic phase was dried over magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure
6. customThe crude product was purified by means of preparative HPLC