1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[4-(2,2,2-trifluoroethyl)phenyl]piperidine-3-carboxylic acid → (4-Hydroxypiperidin-1-yl) {3-(3-isopropoxy-1,2,4-oxadiazol-5-yl)-5-[4-(2,2,2-trifluoroethyl)-phenyl]piperidin-1-yl}methanone

Participants

Reaction Steps

According to General Method 1, 150 mg (0.362 mmol) of the compound from Example 58A and 62.7 mg (0.398 mmol, purity 75%) of isopropyl N′-hydroxyimidocarbamate [G. Zinner, G. Nebel, Arch. Pharm. 1970, 303, 385-390] were reacted. Yield: 41.6 mg (23% of theory).

Provenance & Evidence