Potassium Carbonate → HCID 58116480, compound

Participants

Reaction Conditions

Reaction Steps

110 mg (0.211 mmol) of the compound from Example 67A, 69.3 mg (0.633 mmol) of 3-hydroxyazetidine hydrochloride and 72.9 mg (0.527 mmol) of potassium carbonate were added to 3.5 ml of DMF and heated in a single-mode microwave (Emrys Optimizer) at 150° C. for 20 min. For workup, the reaction solution was combined and filtered, and the residue was purified by means of preparative HPLC. Enantiomer separation of 47.7 mg of the racemate according to Method 8D gave 14.7 mg of the title compound from Example 96 (enantiomer 1) and 17.1 mg of the title compound from Example 97 (enantiomer 2).

Provenance & Evidence