Potassium Carbonate → HCID 58116483, compound

Participants

Reaction Conditions

Reaction Steps

50.5 mg (0.064 mmol, purity 70%) of the compound from Example 67A, 30.2 mg (0.275 mmol) of 3-hydroxyazetidine hydrochloride and 31.7 mg (0.229 mmol) of potassium carbonate were added to 2.1 ml of DMF and heated in a single-mode microwave (Emrys Optimizer) at 150° C. for 20 min. For workup, the reaction solution was combined and filtered, and the residue was purified by means of preparative HPLC. Enantiomer separation of 100 mg of the racemic crude product according to Method 8D gave 7.8 mg of the title compound from Example 98 (enantiomer 1) and 8.0 mg of the title compound from Example 99 (enantiomer 2).

Provenance & Evidence