HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[3-Fluoro-4-(trifluoromethyl)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid → {3-(3-Ethoxy-1,2,4-oxadiazol-5-yl)-5-[3-fluoro-4-(trifluoromethyl)phenyl]piperidin-1-yl}(thiomorpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[3-Fluoro-4-(trifluoromethyl)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58116463 | — |
| Reactant | ethyl N-hydroxyimidocarbamate | HCID 76223295 | — |
| Product | {3-(3-Ethoxy-1,2,4-oxadiazol-5-yl)-5-[3-fluoro-4-(trifluoromethyl)phenyl]piperidin-1-yl}(thiomorpholin-4-yl)methanone | HCID 58116531 | — |
Reaction Steps
According to General Method 4, 151 mg (0.280 mmol) of the compound from Example 85A and 43 mg (0.420 mmol) of ethyl N′-hydroxyimidocarbamate [G. Zinner, G. Nebel, Arch. Pharm. 1970, 303, 385-390] were reacted. Yield: 38 mg (25% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-448dd86778494d4aac87ca5d6aa2f702 |
| Source note | uspto-grants-2011_12 |