Acetic Anhydride → HCID 86736211, compound

HRID 66134Notes

Reaction equation

HRID 66134 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[C:5]([NH:12][C:13]1[CH:19]=[CH:18][C:17](=[O:20])[C:16]([NH2:21])=[CH:15][CH:14]=1)=[CH:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:2].[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[CH2:1]([O:3][C:4](=[O:22])[C:5]([NH:12][C:13]1[CH:19]=[CH:18][C:17](=[O:20])[C:16]([NH:21][C:23](=[O:25])[CH3:24])=[CH:15][CH:14]=1)=[CH:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 86736212HCID 86736212, compound

Product 1

HCID 86736211HCID 86736211, compound

Procedure

A solution of 2-(4-amino-5-oxo-1,3,6-cycloheptatrien-1-ylamino)-2-butenedioic acid diethyl ester (1.7 g, described in Example 1) in acetic anhydride (17 ml) is stirred at room temperature for 16 hr. The solution is evaporated and the residue is dissolved in ethyl acetate. The solution is washed with 1N potassium hydroxide and water, dried over sodium sulfate and evaporated to give a residue of 2-(4-acetylamino-5-oxo-1,3,6-cycloheptatrien-1-ylamino)-2-butenedioic acid diethyl ester.

Workup

  1. customThe solution is evaporated
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. washThe solution is washed with 1N potassium hydroxide and water
  4. dry with materialdried over sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-ca30d2586f9542d38478321388e56554
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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