Hydrochloric Acid → HCID 87568755, compound

Participants

Reaction Steps

0.5 ml of 3 M hydrochloric acid were added to 5 ml of an ethyl acetate solution of the (Z)-(1-methyl-1H-tetrazol-5-yl) phenylmethanone-O-(6-(N-formyl-N-n-pentylamino)pyridin-2-ylmethyl) oxime obtained in Example 1 followed by stirring for 5 hours at room temperature. The pH of the reaction liquid was adjusted to pH 7 by adding aqueous sodium carbonate solution thereto. After extracting with ethyl acetate, the product was washed with water and dried with anhydrous magnesium sulfate followed by distilling off the solvent. The resulting residue was purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=2/1 (v/v)) to obtain 0.14 g of (Z)-(6-n-pentylaminopyridin-2-yl)methoxyimino-(1-methyl-1H-tetrazol-5-yl)phenylmethane (compound no. 1-6 in the previous tables).

Provenance & Evidence