HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 4-(piperazin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 4-(piperazin-1-yl)benzoate | HCID 2761178 | — |
Reaction Steps
A mixture of piperazine (129.2 g), ethyl-4-fluorobenzoate (84 g), and K2CO3 (103.65 g) in DMSO (200 mL) at 120° C. was stirred for 6 hours, poured into water, stirred for 30 minutes, and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084607B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-6a101c1109534367a7ff22727ade7b1a |
| Source note | uspto-grants-2011_12 |