Hydrochloric Acid → 4,7-Dihydro-4,7-dioxo-6-methoxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic Acid

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Reaction Steps

A mixture of 4,7-dihydro-4,7-dioxo-6-methoxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (2.89 g, described in Example 7) and 1N potassium hydroxide (11 ml) is stirred at room temperature for 16 hr. Hydrochloric acid (10%) is added until the solution is acidic. The precipitate is collected, washed with water and acetone and crystallized from acetic acid to obtain crystals of the title compound, mp > 250° C.

Provenance & Evidence