4,7-dihydro-4,7-dioxo-6-methoxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester → HCID 22755658, compound

Participants

Reaction Steps

A solution of 4,7-dihydro-4,7-dioxo-6-methoxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (2.0 g, described in Example 7) and 19% hydrochloric acid (60 ml) is refluxed for 30 min. The precipitate is collected and washed with water and acetone to give the title compound. The precipitate is dissolved in aqueous aminoethanol (1M, 4 ml) and acetone (50 ml) is added. The precipitate is collected, washed with acetone and crystallized from water-acetone to give crystals of the aminoethanol salt of the title compound, mp 236°-237° C.

Provenance & Evidence