HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4,7-Dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4,7-dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester | HCID 53803961 | — |
| Product | 4,7-Dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic Acid | HCID 22755643 | — |
Reaction Steps
A mixture of 4,7-dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (8.2 g, described in Example 7) and 19% hydrochloric acid (246 ml) is refluxed for 30 min and cooled to room temperature. The crystalline precipitate is collected and washed with water to give the title compound, mp 227°-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04130649 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-56a48252e6cf48029f9004ca345d63f1 |
| Source note | uspto-grants-1978_12 |